Mycophenolate mofetil is used for the prevention of organ rejection in transplant patients.
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Consumption of alcohol can worsen the condition and increase the risk of side effects.
Phenocept 500mg Tablet is categorized as unsafe during pregnancy (Category D). It can cause birth defects in the fetus. It is not recommended for use in pregnant women.
Phenocept 500mg Tablet is not recommended for breastfeeding mothers, as it may be excreted in breast milk. However, if the benefits outweigh the risks, your doctor may prescribe it.
Taking Phenocept 500mg Tablet may not significantly affect your ability to drive. Consult your doctor for advice based on your health condition.
Use Phenocept 500mg Tablet with caution if you have kidney disease. Dose adjustments might be necessary.
Use Phenocept 500mg Tablet with caution if you have liver disease. Dose adjustments might be necessary.
Phenocept 500mg Tablet works by suppressing the immune system so that the body does not reject the transplanted organ.
The main adverse effects linked to Mycophenolate Mofetil include diarrhea, reduced white blood cell count, sepsis, gastrointestinal candidiasis, urinary tract infection, herpes simplex infection, and vomiting. Moreover, there's an indication of an increased occurrence of specific infections, especially opportunistic ones.
Mycophenolate Mofetil, combined with corticosteroids and either ciclosporin or tacrolimus, is used for:
Mycophenolate mofetil is derived from mycophenolic acid (MPA) through the 2-morpholino ethyl ester. MPA acts as a potent, selective, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This action leads to the inhibition of the de novo pathway for the synthesis of guanosine nucleotides. The mechanism by which MPA hinders IMPDH's enzymatic activity involves structural resemblance to both the cofactor nicotinamide adenine dinucleotide and a catalytic water molecule. This structural mimicry prevents the oxidation of inosine monophosphate (IMP) to xanthosine-5'-monophosphate, a crucial step in the biosynthesis of guanosine nucleotides.
MPA has a particularly strong impact on lymphocytes, more so than other cell types. T- and B-lymphocytes heavily rely on the de novo synthesis of purines for their proliferation, whereas other cell types can utilize salvage pathways. Mycophenolic acid, the metabolically active form of mycophenolate mofetil, acts as a non-competitive, reversible inhibitor of IMPDH. This inhibition effectively halts the de novo synthesis of guanosine nucleotides, which are crucial building blocks for DNA and RNA synthesis. While other cell types can use alternative pathways, B and T lymphocytes depend on the de novo pathway for the generation of guanosine.
In vitro, studies demonstrate that mycophenolic acid and/or mycophenolate mofetil can suppress mixed lymphocyte responses and the proliferation of human peripheral blood lymphocytes in response to various stimulants like mitogens and antigens. Mycophenolic acid also reduces the intracellular levels of guanosine triphosphate (GTP) and deoxyguanosine triphosphate (dGTP) in human peripheral blood monocytes or T lymphocytic cell lines activated by mitogens. Notably, mycophenolic acid does not influence GTP concentrations in human neutrophils.
Adult Dosage:
Child Dosage:
Renal Impairment:
Administration:
When taking Phenocept 500mg Tablet, it's important to carefully consider the concomitant use of the following medicines:
Do not take Phenocept 500mg Tablet if:
Mycophenolate Mofetil is contraindicated in pregnancy and during breastfeeding. The safe use of Mycophenolate Mofetil during labor and delivery has not been established.
Mycophenolate mofetil poses a risk of causing birth defects in animals, therefore, prevent inhalation or direct contact with the skin. Patients should be observed for lymphoproliferative disorders, and they should be advised to restrict exposure to sunlight and UV light. Regular complete blood cell counts (CBCs) should be performed to monitor for neutropenia. It's important to note that mycophenolate mofetil and mycophenolate sodium are not interchangeable.
For lactating individuals, it is uncertain whether the drug is excreted in breast milk, hence it is advised to avoid using it or not to nurse while on treatment.
Store at a temperature below 30º C in a cool and dry place. Keep it out of the reach of children and pets.
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